Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
Autor(es): Chen Karen Caiyun, Kam Yiu-Wing, Lin Raymond Tzer Pin, Ng Mary Mah-Lee, Ng Lisa Fp, Chu Justin Jang Hann
Resumo: A comparative analysis of the genomic - replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central - South African (ECSA) lineage was performed. Analysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 - E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates. These findings provide insights into the genomic - replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage.
Palavras-Chave: Chikungunya virus; Genome sequencing; Virus morphogenesis; Virus replication kinetics
Imprenta: Virology Journal, v. 10, p. 169, 2013
Identificador do objeto digital: 10.1186/1743-422X-10-169
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya Virus - Virus
Data de publicação: 2013
