Autor(es)Nkoghe Dieudonné, Kassa Roland Fabrice, Caron Mélanie, Grard Gilda, Mombo Illich, Bikié Branly, Paupy Christophe, Becquart Pierre, Bisvigou Ulrich, Leroy Eric Maurice

ResumoChikungunya virus (CHIKV) has caused multiple outbreaks in tropical - temperate areas worldwide, but the clinical - biological features of this disease are poorly described, particularly in Africa. We report a prospective study of clinical - biological features during an outbreak that occurred in Franceville, Gabon in 2010. We collected, in suspect cases (individuals presenting with at least one of the following symptoms or signs: fever, arthralgias, myalgias, headaches, rash, fatigue, nausea, vomiting, diarrhea, bleeding, or jaundice), blood samples, demographic - clinical characteristics - outcome. Hematological - biochemical tests, blood smears for malaria parasites - quantitative PCR for CHIKV then dengue virus were performed. CHIKV+ patients with concomitant malaria -/or dengue were excluded from the study. From May to July 2010, data on 270 laboratory-confirmed CHIK patients were recorded. Fever - arthralgias were reported by respectively 85% - 90% of patients, while myalgias, rash - hemorrhage were noted in 73%, 42% - 2% of patients. The patients were grouped into 4 clinical categories depending on the existence of fever -/or joint pain. On this basis, mixed forms accounted for 78.5% of cases, arthralgic forms 12.6%, febrile forms 6.7% - unusual forms (without fever - arthralgias) 2.2%. No cases of organ failure or death were reported. Elevated liver enzyme - creatinine levels, anemia - lymphocytopenia were the predominant biological abnormalities, - lymphocytopenia was more severe in patients with high viral loads (p = 0.01). During CHIK epidemics, some patients may not have classical symptoms. The existence of unusual forms - the absence of severe forms of CHIK call for surveillance to detect any change in pathogenicity.

ImprentaPLoS Neglected Tropical Diseases, v. 6, n. 2, p. e1517, 2012

DescritoresChikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de Publicação:2012