Autor(es): Nkoghe Dieudonné, Kassa Roland Fabrice, Caron Mélanie, Grard Gilda, Mombo Illich, Bikié Branly, Paupy Christophe, Becquart Pierre, Bisvigou Ulrich, Leroy Eric Maurice

Resumo: Chikungunya virus (CHIKV) has caused multiple outbreaks in tropical - temperate areas worldwide, but the clinical - biological features of this disease are poorly described, particularly in Africa. We report a prospective study of clinical - biological features during an outbreak that occurred in Franceville, Gabon in 2010. We collected, in suspect cases (individuals presenting with at least one of the following symptoms or signs: fever, arthralgias, myalgias, headaches, rash, fatigue, nausea, vomiting, diarrhea, bleeding, or jaundice), blood samples, demographic - clinical characteristics - outcome. Hematological - biochemical tests, blood smears for malaria parasites - quantitative PCR for CHIKV then dengue virus were performed. CHIKV+ patients with concomitant malaria -/or dengue were excluded from the study. From May to July 2010, data on 270 laboratory-confirmed CHIK patients were recorded. Fever - arthralgias were reported by respectively 85% - 90% of patients, while myalgias, rash - hemorrhage were noted in 73%, 42% - 2% of patients. The patients were grouped into 4 clinical categories depending on the existence of fever -/or joint pain. On this basis, mixed forms accounted for 78.5% of cases, arthralgic forms 12.6%, febrile forms 6.7% - unusual forms (without fever - arthralgias) 2.2%. No cases of organ failure or death were reported. Elevated liver enzyme - creatinine levels, anemia - lymphocytopenia were the predominant biological abnormalities, - lymphocytopenia was more severe in patients with high viral loads (p = 0.01). During CHIK epidemics, some patients may not have classical symptoms. The existence of unusual forms - the absence of severe forms of CHIK call for surveillance to detect any change in pathogenicity.

Imprenta: PLoS Neglected Tropical Diseases, v. 6, n. 2, p. e1517, 2012

Identificador do objeto digital: 10.1371/journal.pntd.0001517

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2012

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