Autor(es): de Andrade Daniel Ciampi, Jean Sylvain, Clavelou Pierre, Dallel Radhouane, Bouhassira Didier

Resumo: Chikungunya virus (CHIKV) is responsible for major epidemics worldwide. Autochthonous cases were recently reported in several European countries. Acute infection is thought to be monophasic. However reports on chronic pain related to CHIKV infection have been made. In particular, the fact that many of these patients do not respond well to usual analgesics suggests that the nature of chronic pain may be not only nociceptive but also neuropathic. Neuropathic pain syndromes require specific treatment - the identification of neuropathic characteristics (NC) in a pain syndrome is a major step towards pain control. We carried out a cross-sectional study at the end of the major two-wave outbreak lasting 17 months in Réunion Isl-. We assessed pain in 106 patients seeking general practitioners with confirmed infection with the CHIK virus, - evaluated its impact on quality of life (QoL). The mean intensity of pain on the visual-analogical scale (VAS) was 5.8 +/- 2.1, - its mean duration was 89 +/- 2 days. Fifty-six patients fulfilled the definition of chronic pain. Pain had NC in 18.9% according to the DN4 questionnaire. Conversely, about two thirds (65%) of patients with NC had chronic pain. The average pain intensity was similar between patients with or without NC (6.0 +/- 1.7 vs 6.1 +/- 2.0). However, the total score of the Short Form-McGill Pain Questionnaire (SF-MPQ)(15.5 +/- 5.2 vs 11.6 +/- 5.2; p < 0.01) - both the affective (18.8 +/- 6.2 vs 13.4 +/- 6.7; p < 0.01) - sensory subscores (34.3 +/- 10.7 vs 25.0 +/- 9.9; p < 0.01) were significantly higher in patients with NC. The mean pain interference in life activities calculated from the Brief Pain Inventory (BPI) was significantly higher in patients with chronic pain than in patients without it (6.8 +/- 1.9 vs 5.9 +/- 1.9, p < 0.05). This score was also significantly higher in patients with NC than in those without such a feature (7.2 +/- 1.5 vs 6.1 +/- 1.9, p < 0.05). There exists a specific chronic pain condition associated to CHIKV. Pain with NC seems to be associated with more aggressive clinical picture, more intense impact in QoL - more challenging pharmacological treatment.

Imprenta: BMC Infectious Diseases, v. 10, p. 31, 2010

Identificador do objeto digital: 10.1186/1471-2334-10-31

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2010

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