Chikungunya: evolutionary history and recent epidemic spread
Autor(es): Weaver Scott C, Forrester Naomi L
Resumo: Chikungunya virus (CHIKV) has a long history of emergence into urban transmission cycles from its ancestral, enzootic, sylvatic foci in Sub-Saharan Africa, most recently spreading to the Americas beginning in 2013. Since 2004, reemergence has resulted in millions of cases of severe, debilitating - often chronic arthralgia on five continents. Here, we review this history based on phylogenetic studies, - discuss probable future spread - disease in the Americas. We also discuss a series of mutations in the recently emerged Indian Ocean Lineage that has adapted the virus for transmission for the first time by the Aedes albopictus urban mosquito vector, - compare CHIKV to other arboviruses with - without similar histories of urbanization. This article forms part of a symposium in Antiviral Research on Chikungunya discovers the New World.""
Palavras-Chave: Alphavirus; Arbovirus; Arthralgia; Chikungunya; Mosquito; Urbanization
Imprenta: Antiviral Research, v. 120, p. 32-39, 2015
Identificador do objeto digital: 10.1016/j.antiviral.2015.04.016
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Biochemistry ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2015
