Autor(es): Schilte Clémentine, Staikowsky Frederik, Staikovsky Frédérik, Couderc Thérèse, Madec Yoann, Carpentier Florence, Kassab Somar, Albert Matthew L, Lecuit Marc, Michault Alain

Resumo: Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever - arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Isl-, during which we constituted a prospective cohort of viremic patients (n = 180) - defined the clinical - biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya. Patients were submitted to clinical investigations 4, 6, 14 - 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia - 20 patients without arthralgia were r-omly selected from the cohort - consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse - recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) - highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years - the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia - permitted an estimation of the economic burden associated with arthralgia. This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease - suggests that it results from a local rather than systemic inflammation.

Imprenta: PLoS Neglected Tropical Diseases , v. 7, n. 3, p. e2137, 2013

Identificador do objeto digital: 10.1371/journal.pntd.0002137

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2013

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