Autor(es)Schilte Clémentine, Staikowsky Frederik, Staikovsky Frédérik, Couderc Thérèse, Madec Yoann, Carpentier Florence, Kassab Somar, Albert Matthew L, Lecuit Marc, Michault Alain

ResumoArthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever - arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Isl-, during which we constituted a prospective cohort of viremic patients (n = 180) - defined the clinical - biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya. Patients were submitted to clinical investigations 4, 6, 14 - 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia - 20 patients without arthralgia were r-omly selected from the cohort - consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse - recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) - highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years - the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia - permitted an estimation of the economic burden associated with arthralgia. This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease - suggests that it results from a local rather than systemic inflammation.

ImprentaPLoS Neglected Tropical Diseases , v. 7, n. 3, p. e2137, 2013

DescritoresChikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2013