Autor(es): Singh Sunit Kumar, Unni Salini Krishnan

Resumo: Chikungunya is a re-emerging arthropod-borne viral disease caused by Chikungunya virus (CHIKV) belonging to the Togaviridae family of genus Alphavirus. It is a virus with a single str-ed, positive sense RNA, as its genome. It is maintained in a sylvatic - urban cycle involving humans - the mosquito species Aedes aegypti - Aedes albopictus. It has garnered the attention of scientists in the past 5-6 years due to the massive outbreaks in the Indian Ocean region in 2005-2006. It has a major health impact on humans as it causes fever, rashes, arthralgia - myalgia. Polyarthralgia is the most important feature of CHIKV infection which primarily affects the small joints of the wrists - fingers along with the large joints like shoulders - knees. Currently, there are no vaccines or treatment regimens available for CHIKV infection. The molecular mechanism underlying the chronic polyarthralgia observed in patients is not well understood. In this review we have summarized the CHIKV organization, replication, epidemiology, clinical manifestations - pathogenesis with emphasis on the arthralgia.

Imprenta: Reviews in Medical Virology, v. 21, n. 2, p. 78-88, 2011

Identificador do objeto digital: 10.1002/rmv.681

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Molecular screening ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2011

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