Chikungunya virus was isolated in Thailand, 2010
Autor(es): Sasayama Mikiko, Benjathummarak Surachet, Kawashita Norihito, Rukmanee Prasert, Sangmukdanun Suntaree, Masrinoul Promsin, Pitaksajjakul Pannamthip, Puiprom Orapim, Wuthisen Pitak, Kurosu Takeshi, Chaichana Panjaporn, Maneekan Pannamas, Ikuta Kazuyoshi, Ramasoota Pongrama, Okabayashi Tamaki, Singhasivanon Pratap, Luplertlop Natthanej
Resumo: Chikungunya fever (CHIKF) is an acute febrile illness caused by a mosquito-borne alphavirus, chikungunya virus (CHIKV). This disease re-emerged in Kenya in 2004, - spread to the countries in - around the Indian Ocean. The re-emerging epidemics rapidly spread to regions like India - Southeast Asia, - it was subsequently identified in Europe in 2007, probably as a result of importation of chikungunya cases. On the one h-, chikungunya is one of the neglected diseases - has only attracted strong attention during large outbreaks. In 2008-2009, there was a major outbreak of chikungunya fever in Thail-, resulting in the highest number of infections in any country in the region. However, no update of CHIKV circulating in Thail- has been published since 2009. In this study, we examined the viral growth kinetics - sequences of the structural genes derived from CHIKV clinical isolates obtained from the serum specimens of CHIKF-suspected patients in Central Thail- in 2010. We identified the CHIKV harboring two mutations E1-A226V - E2-I211T, indicating that the East, Central, - South African lineage of CHIKV was continuously circulating as an indigenous population in Thail-.
Palavras-Chave: Chikungunya virus; Thailand; Virus replication; Genetic variation
Imprenta: Virus Genes, v. 49, n. 3, p. 485-489, 2014
Identificador do objeto digital: 10.1007/s11262-014-1105-5
Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - DNA ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2014
