Chikungunya virus vaccines: current strategies and prospects for developing plant-made vaccines
Autor(es): Salazar-González Jorge A, Angulo Carlos, Rosales-Mendoza Sergio
Resumo: Chikungunya virus is an emerging pathogen initially found in East Africa - currently spread into the Indian Ocean Isl-s, many regions of South East Asia, - in the Americas. No licensed vaccines against this eminent pathogen are available - thus intensive research in this field is a priority. This review presents the current scenario on the developments of Chikungunya virus vaccines - identifies the use of genetic engineered plants to develop attractive vaccines. The possible avenues to develop plant-made vaccines with distinct antigenic designs - expression modalities are identified - discussed considering current trends in the field.
Palavras-Chave: E antigen; Edible crop; Oral vaccine; Transgenic plant; Transient expression; Transplastomic plant; Vaccine cost; Virus like particles
Imprenta: Vaccine, v. 33, n. 31, p. 3650-3658, 2015
Identificador do objeto digital: 10.1016/j.vaccine.2015.05.104
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology
Data de publicação: 2015
