Autor(es): Vega-Rúa Anubis, Lourenço-de-Oliveira Ricardo, Mousson Laurence, Vazeille Marie, Fuchs Sappho, Yébakima André, Gustave Joel, Girod Romain, Dusfour Isabelle, Leparc-Goffart Isabelle, Vanlandingham Dana L, Huang Yan-Jang S, Lounibos L Philip, Mohamed Ali Souand, Nougairede Antoine, de Lamballerie Xavier, Failloux Anna-Bella

Resumo: Chikungunya virus (CHIKV), mainly transmitted in urban areas by the mosquitoes Aedes aegypti - Aedes albopictus, constitutes a major public health problem. In late 2013, CHIKV emerged on Saint-Martin Isl- in the Caribbean - spread throughout the region reaching more than 40 countries. Thus far, Ae. aegypti mosquitoes have been implicated as the sole vector in the outbreaks, leading to the hypothesis that CHIKV spread could be limited only to regions where this mosquito species is dominant. We determined the ability of local populations of Ae. aegypti - Ae. albopictus from the Americas - Europe to transmit the CHIKV strain of the Asian genotype isolated from Saint-Martin Isl- (CHIKV_SM) during the recent epidemic, - an East-Central-South African (ECSA) genotype CHIKV strain isolated from La Réunion Isl- (CHIKV_LR) as a well-characterized control virus. We also evaluated the effect of temperature on transmission of CHIKV_SM by European Ae. albopictus. We found that (i) Aedes aegypti from Saint-Martin Isl- transmit CHIKV_SM - CHIKV_LR with similar efficiency, (ii) Ae. aegypti from the Americas display similar transmission efficiency for CHIKV_SM, (iii) American - European populations of the alternative vector species Ae. albopictus were as competent as Ae. aegypti populations with respect to transmission of CHIKV_SM - (iv) exposure of European Ae. albopictus to low temperatures (20°C) significantly reduced the transmission potential for CHIKV_SM. CHIKV strains belonging to the ECSA genotype could also have initiated local transmission in the new world. Additionally, the ongoing CHIKV outbreak in the Americas could potentially spread throughout Ae. aegypti- - Ae. albopictus-infested regions of the Americas with possible imported cases of CHIKV to Ae. albopictus-infested regions in Europe. Colder temperatures may decrease the local transmission of CHIKV_SM by European Ae. albopictus, potentially explaining the lack of autochthonous transmission of CHIKV_SM in Europe despite the hundreds of imported CHIKV cases returning from the Caribbean.

Imprenta: PLoS Neglected Tropical Diseases, v. 9, n. 5, p. e0003780, 2015

Identificador do objeto digital: 10.1371/journal.pntd.0003780

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemic ; Chikungunya virus - Public health

Data de publicação: 2015

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