Chikungunya virus susceptibility & variation in populations of Aedes aegypti (Diptera: Culicidae) mosquito from India
Autor(es): Gokhale Mangesh D, Paingankar Mandar S, Sudeep Anakathil B, Parashar Deepti
Resumo: Although having immense clinical relevance, yet only a few studies have been targeted to underst- the chikungunya virus (CHIKV) susceptibility - growth in Aedes aegypti populations from India. This study was undertaken to investigate CHIKV susceptibility - growth kinetics in Ae. aegypti along with genetic heterogeneity of Ae. aegypti populations. Dose dependent CHIKV susceptibility - growth kinetic studies for three CHIKV strains reported from India were carried out in Ae. aegypti mosquito populations. The phenotypic variation - genetic heterogeneity in five Ae. aegypti populations were investigated using multivariate morphometrics - allozyme variation studies. The dissemination - growth kinetics studies of the three CHIKV strains showed no selective advantage for a particular strain of CHIKV in Ae. aegypti. At 100 per cent infection rate, five geographic Ae. aegypti populations showed differences in dissemination to three CHIKV strains. Morphometric studies revealed phenotypic variation in all the studied populations. The allelic frequencies, F statistics, - Nei's genetic identity values showed that genetic differences between the populations were small, but significant. The results obtained in this study suggest that genetic background of the vector strongly influences the CHIKV susceptibility in Ae. aegypti.
Imprenta: The Indian Journal of Medical Research, v. 142, p. 33-43, 2015
Identificador do objeto digital: 10.4103/0971-5916.176614
Descritores: Chikungunya Virus - Virus
Data de publicação: 2015
