Chikungunya virus pathogenesis: From bedside to bench
Autor(es): Couderc Thérèse, Lecuit Marc
Resumo: Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the isl-s of the Indian Ocean, then reached India - Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean - now extending to Central, South - North America. It is therefore considered a major public health - economic threat. CHIKV causes febrile illness typically associated with debilitating joint pains. In rare cases, it may also cause central nervous system disease, notably in neonates. Joint symptoms may persist for months to years, - lead to arthritis. This review focuses on the spectrum of signs - symptoms associated with CHIKV infection in humans. It also illustrates how the analysis of clinical - biological data from human cohorts - the development of animal - cellular models of infection has helped to identify the tissue - cell tropisms of the virus - to decipher host responses in benign, severe or persistent disease. This article forms part of a symposium in Antiviral Research on Chikungunya discovers the New World"."
Palavras-Chave: Arbovirus; Arthralgia; Chikungunya virus; Emerging virus; Mosquito-borne
Imprenta: Antiviral Research, v. 121, p. 120-131, 2015
Identificador do objeto digital: 10.1016/j.antiviral.2015.07.002
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Public health
Data de publicação: 2015
