Chikungunya virus impacts the diversity of symbiotic bacteria in mosquito vector
Autor(es): Zouache Karima, Michelland Rory J, Failloux Anna-Bella, Grundmann Genevieve L, Mavingui Patrick
Resumo: Mosquitoes transmit numerous arboviruses including dengue - chikungunya virus (CHIKV). In recent years, mosquito species Aedes albopictus has exp-ed in the Indian Ocean region - was the principal vector of chikungunya outbreaks in La Reunion - neighbouring isl-s in 2005 - 2006. Vector-associated bacteria have recently been found to interact with transmitted pathogens. For instance, Wolbachia modulates the replication of viruses or parasites. However, there has been no systematic evaluation of the diversity of the entire bacterial populations within mosquito individuals particularly in relation to virus invasion. Here, we investigated the effect of CHIKV infection on the whole bacterial community of Ae. albopictus. Taxonomic microarrays - quantitative PCR showed that members of Alpha- - Gammaproteobacteria phyla, as well as Bacteroidetes, responded to CHIKV infection. The abundance of bacteria from the Enterobacteriaceae family increased with CHIKV infection, whereas the abundance of known insect endosymbionts like Wolbachia - Blattabacterium decreased. Our results clearly link the pathogen propagation with changes in the dynamics of the bacterial community, suggesting that cooperation or competition occurs within the host, which may in turn affect the mosquito traits like vector competence.
Imprenta: Molecular Ecology, v. 21, n. 9, p. 2297-2309, 2012
Identificador do objeto digital: 10.1111/j.1365-294X.2012.05526.x
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Public health
Data de publicação: 2012
