Chikungunya virus adapts to tiger mosquito via evolutionary convergence: A sign of things to come?
Autor(es): de Lamballerie Xavier, Leroy Eric, Charrel Rémi N, Ttsetsarkin Konstantin, Higgs Stephen, Gould Ernest A
Resumo: Since 2004, several million indigenous cases of Chikungunya virus disease occurred in Africa, the Indian Ocean, India, Asia -, recently, Europe. The virus, usually transmitted by Aedes aegypti mosquitoes, has now repeatedly been associated with a new vector, Ae. Albopictus. Analysis of full-length viral sequences reveals three independent events of virus exposure to Ae. Albopictus, each followed by the acquisition of a single adaptive mutation providing selective advantage for transmission by this mosquito. This disconcerting - current unique example of evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities."
Imprenta: Virology Journal, v. 5, p. 33, 2008
Identificador do objeto digital: 10.1186/1743-422X-5-33
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2008
