Autor(es): Miner Jonathan J, Aw Yeang Han Xian, Fox Julie M, Taffner Samantha, Malkova Olga N, Oh Stephen T, Kim Alfred H J, Diamond Michael S, Lenschow Deborah J, Yokoyama Wayne M

Resumo: Chikungunya virus (CHIKV) is an arthritogenic mosquito-transmitted alphavirus that spread to the Caribbean in 2013 - to the US in 2014. CHIKV-infected patients develop inflammatory arthritis that can persist for months or years, but little is known about the rheumatologic - immunologic features of CHIKV-related arthritis in humans, particularly as compared to rheumatoid arthritis (RA). The purpose of this study was to describe these features in a group of 10 American travelers who were nearly simultaneously infected while visiting Haiti in June 2014. Patient history was obtained - physical examination - laboratory tests were performed. All patients with CHIKV-related arthritis had detectable levels of anti-CHIKV IgG. Using cytometry by time-of-flight (CyTOF), we analyzed peripheral blood mononuclear cells in CHIKV-infected patients, healthy controls, - patients with untreated, active RA. Among 10 CHIKV-infected individuals, 8 developed persistent symmetric polyarthritis that met the American College of Rheumatology/European League Against Rheumatism 2010 criteria for (seronegative) RA. CyTOF analysis revealed that RA - CHIKV-infected patients had greater percentages of activated - effector CD4+ - CD8+ T cells than healthy controls. In addition to similar clinical features, patients with CHIKV infection - patients with RA develop very similar peripheral T cell phenotypes. These overlapping clinical - immunologic features highlight a need for rheumatologists to consider CHIKV infection when evaluating patients with new, symmetric polyarthritis.

Imprenta: Arthritis & Rheumatology, v. 67, n. 5, p. 1214-1220, 2015

Identificador do objeto digital: 10.1002/art.39027

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - T lymphocytes ; Chikungunya virus - Viral infections ; Chikungunya virus - Clinical examination ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2015

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