Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia
Autor(es): Mohd Zim M A, Sam I-C, Omar S F Syed, Chan Y F, AbuBakar S, Kamarulzaman A
Resumo: Chikungunya virus (CHIKV) - dengue virus (DENV) co-circulate in areas endemic with the Aedes mosquito vectors. Both viruses cause similar illnesses which may be difficult to distinguish clinically. CHIKV is also associated with persistent arthralgia. To compare - describe factors which differentiate between DENV - CHIKV infections on presentation; - to describe predictors of persistent arthralgia in CHIKV patients. Patients aged >14 years diagnosed with acute CHIKV - DENV infections in Kuala Lumpur, Malaysia were retrospectively identified. Clinical - laboratory data were obtained from medical records, - compared. CHIKV patients were telephoned 15-24 months later - interviewed about persistent symptoms. Logistic regression analysis was performed. A total of 53 CHIKV - 113 DENV patients were included. CHIKV patients were older - more likely to be female. CHIKV was independently associated with arthralgia - rash, while DENV was associated with myalgia, raised aspartate transaminase, - leucopaenia. Forty CHIKV patients were followed up, with a median duration of self-reported arthralgia of 3 months (range, 0-24 months). Eighteen (45%) had persistent arthralgia beyond 4 months, for which age >40 years was an independent predictor. At 1 year, 9 (22.5%) patients had arthralgia. In Kuala Lumpur, selected clinical - laboratory predictors help to distinguish between DENV - CHIKV infections. Persistent arthralgia was a frequent sequel of CHIKV infection in this cohort.
Palavras-Chave: Chikungunya virus; Dengue virus; Malaysia; Arthralgia; Rash; Differential diagnosis
Imprenta: Journal of Clinical Virology, v. 56, n. 2, p. 141-145, 2013
Identificador do objeto digital: 10.1016/j.jcv.2012.10.019
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2013
