Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006
Autor(es): Panning Marcus, Grywna Klaus, van Esbroeck Marjan, Emmerich Petra, Drosten Christian
Resumo: Chikungunya fever has spread through several Indian Ocean isl-s - India, including popular travel destinations. To compare usefulness of diagnostic tests - to underst- reasons for the magnitude - severity of an outbreak, we used 3 diagnostic methods to test 720 samples from 680 patients returning to Europe from the Indian Ocean region in 2006. Chikungunya infection was confirmed for 24.4% patients in the first half of the year - for 9.9% in the second half. Reverse transcription-PCR was positive for all samples taken up to day 4 after symptom onset. Immunofluorescence detected immunoglobulin (Ig) M on day 1 - IgG on day 2 for some patients, - in all patients from day 5 onward. Soon after onset of symptoms, patients had IgG - IgM - high viral loads (some >10(9) copies/mL plasma). These data will help healthcare providers select diagnostic tests for returning travelers.
Imprenta: Emerging Infectious Diseases, v. 14, n. 3, p. 416-422, 2008
Identificador do objeto digital: 10.3201/eid1403.070906
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2008
