Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia
Autor(es)Dupuis-Maguiraga Laurence, Noret Marion, Brun Sonia ,Le Grand Roger, Gras Gabriel, Roques Pierre
ResumoAt the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years - could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants returning to Africa. In humans, it causes a disease characterized by a typical acute infection, sometimes followed by persistent arthralgia - myalgia lasting months or years. Investigations in the La Réunion cohort - studies in a macaque model of chikungunya implicated monocytes-macrophages in viral persistence. In this Review, we consider the relationship between CHIKV - the immune response - discuss predictive factors for chronic arthralgia - myalgia by providing an overview of current knowledge on chikungunya pathogenesis. Comparisons of data from animal models of the acute - chronic phases of infection, - data from clinical series, provide information about the mechanisms of CHIKV infection-associated inflammation, viral persistence in monocytes-macrophages, - their link to chronic signs.
ImprentaPLoS Neglected Tropical Diseases, v. 6, n. 3, p. e1446, 2012
Identificador do Objeto Digital10.1371/journal.pntd.0001446
DescritoresChikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology
Data de Publicação:2012
