Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia
Autor(es): Dupuis-Maguiraga Laurence, Noret Marion, Brun Sonia ,Le Grand Roger, Gras Gabriel, Roques Pierre
Resumo: At the end of 2005, an outbreak of fever associated with joint pain occurred in La Réunion. The causal agent, chikungunya virus (CHIKV), has been known for 50 years - could thus be readily identified. This arbovirus is present worldwide, particularly in India, but also in Europe, with new variants returning to Africa. In humans, it causes a disease characterized by a typical acute infection, sometimes followed by persistent arthralgia - myalgia lasting months or years. Investigations in the La Réunion cohort - studies in a macaque model of chikungunya implicated monocytes-macrophages in viral persistence. In this Review, we consider the relationship between CHIKV - the immune response - discuss predictive factors for chronic arthralgia - myalgia by providing an overview of current knowledge on chikungunya pathogenesis. Comparisons of data from animal models of the acute - chronic phases of infection, - data from clinical series, provide information about the mechanisms of CHIKV infection-associated inflammation, viral persistence in monocytes-macrophages, - their link to chronic signs.
Imprenta: PLoS Neglected Tropical Diseases, v. 6, n. 3, p. e1446, 2012
Identificador do objeto digital: 10.1371/journal.pntd.0001446
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Immunology
Data de publicação: 2012
