Autor(es)Hertz Julian T, Munishi O Michael, Ooi Eng Eong, Howe Shiqin, Lim Wen Yan, Chow Angelia, Morrissey Anne B, Bartlett John A, Onyango Jecinta J, Maro Venance P, Kinabo Grace D, Saganda Wilbrod, Gubler Duane J, Crump John A

ResumoConsecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), - flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, - prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti-DENV IgM serologic testing was performed for 747 (85.9%) participants, - of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, - of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants - children than adults - adolescents (odds ratio [OR] 1.9, P = 0.026) - among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating.

ImprentaThe American Journal of Tropical Medicine and Hygiene, v. 86, n. 1, p. 171-177, 2012

DescritoresChikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology

Data de Publicação:2012