Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection
Autor(es): Björkström Niklas K, Svensson Alexandra, Malmberg Karl-Johan, Eriksson Kristina, Ljunggren Hans-Gustaf
Resumo: Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, - CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus, chikungunya virus, - HIV-1. Here, we addressed if HSV-2 infection in a similar way drives NK cell differentiation towards an NKG2A(-)NKG2C(+)KIR(+)CD57(+) phenotype. In contrast to infection with CMV, hantavirus, chikungunya virus, - HIV-1, recurrent HSV-2 infection did not yield an accumulation of highly differentiated NK cells in human peripheral blood. This outcome indicates that human HSV-2 infection has no significant imprinting effect on the human NK cell repertoire.
Imprenta: PloS One, v. 6, n. 11, p. e27664, 2011
Identificador do objeto digital: 10.1371/journal.pone.0027664
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 2011
