Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses
Autor(es): Petitdemange Caroline, Wauquier Nadia, Jacquet Jean-Michel, Theodorou Ioannis, Leroy Eric, Vieillard Vincent
Resumo: Natural killer (NK) cells provide defense in the early stages of the immune response against viral infections. Killer cell immunoglobulin-like receptors (KIR) expressed on the surface of NK cells play an important role in regulating NK cell response through recognition of human leukocyte antigen (HLA) class I molecules on target cells. Previous studies have shown that specific KIR/lig- combinations are associated with the outcome of several viral infectious diseases. We investigated the impact of inhibitory - activating KIR - their HLA-class I lig- genotype on the susceptibility to Chikungunya virus (CHIKV) - Dengue virus (DENV2) infections. From April to July 2010 in Gabon, a large outbreak of CHIKV - DENV2 concomitantly occurred in two provinces of Gabon (Ogooué-Lolo - Haut-Ogooué). We performed the genotypic analysis of KIR in the combination with their cognate HLA-class I lig-s in 73 CHIKV - 55 DENV2 adult cases, compared with 54 healthy individuals. We found in CHIV-infected patients that KIR2DL1 - KIR2DS5 are significantly increased - decreased respectively, as compared to DENV2+ patients - healthy donors. The combination of KIR2DL1 - its cognate HLA-C2 lig- was significantly associated with the susceptibility to CHIKV infection. In contrast, no other inhibitory KIR-HLA pairs showed an association with the two mosquito-borne arboviruses. These observations are strongly suggestive that the NK cell repertoire shaped by the KIR2DL1:HLA-C2 interaction facilitate specific infection by CHIKV.
Imprenta: PloS one, v. 9, n. 9, p. e108798, 2014
Identificador do objeto digital: 10.1371/journal.pone.0108798
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Immune response ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2014
