Autor(es)Suhrbier Andreas, Jaffar-B-jee Marie-Christine, Gasque Philippe

ResumoMosquito-transmitted alphaviruses causing human rheumatic disease are globally distributed - include chikungunya virus, Ross River virus, Barmah Forest virus, Sindbis virus, o'nyong-nyong virus - Mayaro virus. These viruses cause endemic disease -, occasionally, large epidemics; for instance, the 2004-2011 chikungunya epidemic resulted in 1.4-6.5 million cases, with imported cases reported in nearly 40 countries. The disease is usually self-limiting - characterized by acute - chronic symmetrical peripheral polyarthralgia-polyarthritis, with acute disease usually including fever, myalgia -/or rash. Arthropathy can be debilitating, usually lasts weeks to months - can be protracted; although adequate attention to differential diagnoses is recommended. The latest chikungunya virus epidemic was also associated with some severe disease manifestations - mortality, primarily in elderly patients with comorbidities - the young. Chronic alphaviral rheumatic disease probably arises from inflammatory responses stimulated by the virus persisting in joint tissues, despite robust antiviral immune responses. Serodiagnosis by ELISA is the st-ard; although international st-ardization is often lacking. Treatment usually involves simple analgesics -/or NSAIDs, which can provide relief, but better drug treatments are clearly needed. However, the small market size -/or the unpredictable - rapid nature of epidemics present major hurdles for development - deployment of new alphavirus-specific interventions.

ImprentaNature Reviews Rheumatology, v. 8, n. 7, p. 420-429, 2012

DescritoresChikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2012