Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission
Autor(es): Forrester Naomi L, Coffey Lark L, Weaver Scott C
Resumo: The term arbovirus denotes viruses that are transmitted by arthropods, such as ticks, mosquitoes, - other biting arthropods. The infection of these vectors produces a certain set of evolutionary pressures on the virus; involving migration from the midgut, where the blood meal containing the virus is processed, to the salivary gl-s, in order to transmit the virus to the next host. During this process the virus is subject to numerous bottlenecks, stochastic events that significantly reduce the number of viral particles that are able to infect the next stage. This article reviews the latest research on the bottlenecks that occur in arboviruses - the way in which these affect the evolution - fitness of these viruses. In particular we focus on the latest research on three important arboviruses, West Nile virus, Venezuelan equine encephalitis virus - Chikungunya viruses - compare the differing effects of the mosquito bottlenecks on these viruses as well as other evolutionary pressures that affect their evolution - transmission.
Palavras-Chave: Bottlenecks; Evolution; Arboviruses; Viral fitness; West Nile virus; Chikungunya virus; Venezuelan equine encephalitis virus
Imprenta: Viruses, v. 6, n. 10, p. 3991-4004, 2014
Identificador do objeto digital: 10.3390/v6103991
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Immunology
Data de publicação: 2014
