Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak
Autor(es): Santhosh S R, Dash Paban Kumar, Parida Manmohan, Khan Mohasin, Rao Putcha V L
Resumo: Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 - 64,548 persons during 2007 - 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology - the mutations involved are useful for further control measures. Among the 2008 outbreaks the Coastal Karnataka accounts for the 46,510 persons. An in-depth investigation of Chikungunya epidemic of Coastal Karnataka, India, 2008 by serology, virus isolation, RT-PCR - genome sequencing revealed the presence - continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector Aedes albopictus - the geographical proximity of coastal Karnataka with the adjoining Kerala state. This is the first report regarding the appearance of this mutation in Karnataka state of India. The present study identified the presence - association of A226V mutant virus with Chikungunya outbreak in India during 2008.
Imprenta: Virology Journal, v. 6, n. 172, 2009
Identificador do objeto digital: 10.1186/1743-422X-6-172
Descritores: Chikungunya virus - DNA ; Chikungunya virus - Genome ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Serology ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2009
