Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri
Autor(es)Allard Pierre-Marie, Leyssen Pieter, Martin Marie-Thérèse, Bourjot Mélanie, Dumontet Vincent, Eydoux Cécilia, Guillemot Jean-Claude, Canard Bruno, Poullain Cyril, Guéritte Françoise, Litaudon Marc
ResumoThe chemical study of the bark - the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A-F - trigocherriolides A-D. Herein, we describe the isolation - structure elucidation of the DDO (trigocherrins B-F - trigocherriolides A-D). We also report the antiviral activity of trigocherrins A, B - F (1, 2 - 6) - trigocherriolides A, B - C (7-9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) - dengue virus (DENV).
Palavras-ChaveTrigonostemon cherrieri; Euphorbiaceae; Trigocherrin; Trigocherriolide; Daphnane; Chlorinated diterpenes; Antiviral; Chikungunya virus; Sindbis virus; Semliki forest virus; Dengue virus
ImprentaPhytochemistry, v. 84, p. 160-168, 2012
Identificador do Objeto Digital10.1016/j.phytochem.2012.07.023
DescritoresChikungunya virus - Flaviviridae ; Chikungunya virus - Molecular structure ; Chikungunya Virus - Virus ; Chikungunya virus - Dengue
Data de Publicação:2012
