Autor(es): Moreira Luciano A, Iturbe-Ormaetxe Iñaki, Jeffery Jason A, Lu Guangjin, Pyke Alyssa T, Hedges Lauren M, Rocha Bruno C, Hall-Mendelin Sonja, Day Andrew, Riegler Markus, Hugo Leon E, Johnson Karyn N, Kay Brian H, McGraw Elizabeth A, van den Hurk Andrew F, Ryan Peter A, O'Neill Scott L

Resumo: Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific - relates to Wolbachia priming of the mosquito innate immune system - potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.

Palavras-Chave: Humdisease; Molimmuno

Imprenta: Cell, v. 139, n. 7, p. 1268-1278, 2009

Identificador do objeto digital: 10.1016/j.cell.2009.11.042

Descritores: Chikungunya virus - Cell ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue

Data de publicação: 2009

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