Autor(es): Ayorinde Adenola F, Oyeyiga Ayorinde M, Nosegbe Nwakaego O, Folarin Onikepe A

Resumo: Most febrile patients are often misdiagnosed with malaria due to similar symptoms, such as fever shared by malaria - certain arboviral infections. This study surveyed the incidence of malaria, chikungunya - dengue infections among a number of suspected febrile patients visiting Simawa Health Centre, Ogun State, Nigeria. Venous blood samples were obtained from 60 febrile patients (age 3-70 years) visiting the centre between April - May 2014. The rapid diagnostic test (RDT) was used to detect the presence of chikungunya (CHK) antibodies (IgM), dengue (DEN) virus - antibodies (NS1, IgM - IgG) - malaria parasites (Plasmodium falciparum - Plasmodium vivax). Malarial confirmatory tests were by microscopy - nested polymerase chain reaction (PCR) using the polymorphic region of Glutamate-Rich Protein (GLURP) gene. The complexity of P. falciparum infection in the community also determined by the use of nested PCR. These three mosquito-borne infections were observed in 63% (38) of the patients. The prevalence of CHK, DEN - malarial infections singularly were 11%, 0% - 63%, respectively, whereas malaria with either CHK or DEN infections were 24% (9) - 3% (1), respectively. No subjects were positive for CHK - DEN co-infection. Malarial microscopic confirmation was in 94% (32) of the malaria RDT-positive samples, 50% (17) were successfully analysed by nested PCR - the mean multiplicity of infection was 1.6 (1-3 clones). One patient sample harboured both P. falciparum - P. vivax. The study reports the presence of some arboviral infections having similar symptoms with malaria at Simawa, Ogun State. The proper diagnosis of infectious diseases is important for controlling them.

Palavras-Chave: Chikungunya; Dengue; Febrile; Malaria; Plasmodium falciparum; Plasmodium vivax

Imprenta: Journal of Infection and Public Health, v. 9, n. 1, p. 52-59, 2016

Identificador do objeto digital: 10.1016/j.jiph.2015.06.009

Descritores: Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Public health

Data de publicação: 2016