A structural and functional perspective of alphavirus replication and assembly
Autor(es): Jose Joyce, Snyder Jonathan E, Kuhn Richard J
Resumo: Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for a considerable number of human - animal diseases. Alphavirus members include Chikungunya virus, Sindbis virus, Semliki Forest virus, the western, eastern - Venezuelan equine encephalitis viruses, - the Ross River virus. Alphaviruses can cause arthritic diseases - encephalitis in humans - animals - continue to be a worldwide threat. The viruses are transmitted by blood-sucking arthropods, - replicate in both arthropod - vertebrate hosts. Alphaviruses form spherical particles (65-70 nm in diameter) with icosahedral symmetry - a triangulation number of four. The icosahedral structures of alphaviruses have been defined to very high resolutions by cryo-electron microscopy - crystallographic studies. In this review, we summarize the major events in alphavirus infection: entry, replication, assembly - budding. We focus on data acquired from structural - functional studies of the alphaviruses. These structural - functional data provide a broader perspective of the virus lifecycle - structure, - allow additional insight into these important viruses.
Imprenta: Future Microbiology, v. 4, n. 7, p. 837-856, 2009
Identificador do objeto digital: 10.2217/fmb.09.59
Descritores: Chikungunya virus - Molecular structure ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus
Data de publicação: 2009
