A perspective on targeting non-structural proteins to combat neglected tropical diseases: dengue, west nile and chikungunya viruses
Autor(es): Bhakat Soumendranath, Karubiu Wilson, Jayaprakash Venkatesan, Soliman Mahmoud E S
Resumo: Neglected tropical diseases are major causes of fatality in poverty stricken regions across Africa, Asia - some part of America. The combined potential health risk associated with arthropod-borne viruses (arboviruses); Dengue virus (DENV), West Nile Virus (WNV) - Chikungunya Virus (CHIKV) is immense. These arboviruses are either emerging or re-emerging in many regions with recent documented outbreaks in the United States. Despite several recent evidences of emergence, currently there are no approved drugs or vaccines available to counter these diseases. Non-structural proteins encoded by these RNA viruses are essential for their replication - maturation - thus may offer ideal targets for developing antiviral drugs. In recent years, several protease inhibitors have been sourced from plant extract, synthesis, computer aided drug design - high throughput screening as well as through drug reposition based approaches to target the non-structural proteins. The protease inhibitors have shown different levels of inhibition - may thus provide template to develop selective - potent drugs against these devastating arboviruses. This review seeks to shed light on the design - development of antiviral drugs against DENV, WNV - CHIKV to date. To the best of our knowledge, this review provides the first comprehensive update on the development of protease inhibitors targeting non-structural proteins of three most devastating arboviruses, DENV, WNV - CHIKV.
Palavras-Chave: Chikungunya virus; Dengue virus; Non-structural proteins; Protease inhibitors; West Nile virus
Imprenta: European Journal of Medicinal Chemistry, v. 87, p. 677-702, 2014
Identificador do objeto digital: 10.1016/j.ejmech.2014.10.010
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Flaviviridae ; Chikungunya virus - Molecular structure ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue
Data de publicação: 2014
