Autor(es): Pozzetto B, Garraud O

Resumo: During the last 20 years, the safety of blood products increased dramatically with regard to the infectious risk - notably to that represented by retroviruses (HIV - HTLV) - hepatitis B - C viruses. The aim of this review is to identify the residual - emergent viral threats that could be responsible for the occurring of new contaminations in the receivers of blood products. Beside many other viruses (HHV-8, erythrovirus B19, hepatitis A - E viruses...), a special attention has been paid to emerging arbovirus diseases (West Nile virus infection, dengue, chikungunya) that threaten to occur in the French metropolitan area following the implantation in Europe of the mosquito Aedes albopictus, the main vector of dengue - chikungunya in temperate regions. Another blood-linked risk, notably in United Kingdom - France, is the prion agent responsible for the variant form of the Creutzfeldt-Jakob disease. The review is concluded by a brief overview of the measures aimed to control these emergences, including the exclusion of at-risk donors, the diagnostic tests able to detect a specific agent, the leukocyte reduction of labile blood products, - the physical or chemical treatments aiming the nonspecific inactivation of infectious agents potentially present in blood without impairing significantly the physiological properties of blood compounds. The ability to control prospectively the new viral risks linked to blood products is a challenge for the preservation of the confidence of both clinicians - receivers in the safety of blood transfusion.

Palavras-Chave: Blood safety; Emerging viruses; Arbovirus infections; Dengue; Chikungunya; West Nile virus; Aedes albopictus; Creutzfeldt-Jakob disease variant; Leukocyte reduction; Inactivating treatments

Imprenta: Transfusion Clinique et Biologique, v. 18, n. 2, p. 174-183, 2011

Identificador do objeto digital: 10.1016/j.tracli.2011.01.009

Descritores: Chikungunya virus - Arbovirus; Chikungunya virus - Pathogenesis; Chikungunya virus - Proteins; Chikungunya virus - Infectious diseases; Chikungunya virus - Inflammation; Chikungunya virus - Viral infections; Chikungunya Virus - Virus; Chikungunya virus - Transmission; Chikungunya virus - Dengue; Chikungunya virus - Epidemiology; Chikungunya virus - Public health

Data de publicação: 2011

INDICADORES

ACESSO