Early maternal-fetal transmission of the Chikungunya virus
Autor(es): Touret Yasmina, R-rianaivo Hanitra, Michault Alain, Schuffenecker Isabelle, Kauffmann Edouard, Lenglet Yann, Barau Georges, Fourmaintraux Alain
Resumo: Since the onset of the Chikungunya outbreak in Reunion Isl-, vertical maternal-fetal transmission of the virus has been observed in newborns, but no such transmission has been demonstrated early during pregnancy. We report here the first three cases of maternal-fetal transmission of the Chikungunya virus (CHIKV) before 16 weeks' gestational age. Maternal infections occurred at terms of 12 weeks - 4 days, 15 weeks - 5 days, - 15 weeks - were confirmed by positive findings for specific anti-CHIKV IgM. Fetal deaths were subsequently observed, - at that point, CHIKV RT-PCR was negative for all three maternal blood samples. Amniocentesis preceded rupture of membranes in all three cases. RT-PCR showed viral genome in the amniotic fluid of the three fetuses, in the placentas of two, - in the brains of two. Autopsy found no malformations, - all other bacterial - viral test results were negative. These findings demonstrate early maternal-fetal transmission of CHIKV, which is suspected to be directly linked to the fetal deaths. This vertical transmission, probably abortifacient, should be considered in the light of human - animal responses to other arboviruses.
Imprenta: La Presse Me?dicale, v. 35, n. 11, Pt 1, p. 1656-1658, 2006
Identificador do objeto digital: 10.1016/S0755-4982(06)74874-6
Descritores: Chikungunya virus - Arbovirus; Chikungunya virus - Genome; Chikungunya virus - Pathogenesis; Chikungunya virus - Viral infections; Chikungunya virus - RT-PCR; Chikungunya Virus - Virus; Chikungunya virus - Transmission; Chikungunya virus - Public health
Data de publicação: 2006
