Chikungunya virus infections in children
Autor(es): Haas H, Robin S, Ramful D, Houdon L, Minodier P, Gérardin P
Resumo: Chikungunya fever is an arbovirosis caused by an alphavirus (CHIKV) belonging to the Togaviridae family. Its main vectors are Aedes mosquitoes. In its classic form, Chikungunya consists in a flu-like illness that can be very disabling, especially by incapacitating arthralgia. In children, the arthropathy is well known to be better tolerated than in adulthood but severe manifestations - complications can occur owing to neurologic, cardiac, hematologic or cutaneous dysfunctions, all carrying a fatality risk in the absence of appropriate intensive care. Out of these, the most singular is a severe encephalopathy, even in some cases genuine encephalitis. More rare, but quite specific of small infants, skin blisters have been reported, sometimes complicated by extensive detachments. Mother-to-child infections were demonstrated on La Réunion isl- with a fifty-percent probability of vertical transmission when the mother was highly viremic around the term of pregnancy. The diagnosis can be made by detecting CHIKV RNA using RT-PCR or specific IgM antibodies using MAC-Elisa serology. Chikungunya is a notifiable disease. The epidemic that emerged in Indian Ocean isl-s during 2005-2006, its progressive extension to Asia - even to Italy in July 2007, highlighted a very important capacity of CHIKV to cause huge outbreaks wherever Aedes sp. can proliferate. In France, Aedes albopictus is definitively endemic in the departments of Alpes-Maritimes since 2004, Corsica since 2005, - Var since 2007. Therefore, the risk of introduction of CHIKV from an epidemic area to Europe - especially in France is real.
Palavras-Chave: Arboviroses; Chikungunya; Aedes albopictus; Nouveau-né
Imprenta: Archives de Pe?diatrie, v.16, supl 2, p. S72-S79, 2009
Identificador do objeto digital: 10.1016/S0929-693X(09)75305-9
Descritores: Chikungunya virus - Pathogenesis; Chikungunya virus - Proteins; Chikungunya virus - RNA; Chikungunya virus - Antibodies; Chikungunya virus - Serology; Chikungunya virus - Viral infections; Chikungunya virus - RT-PCR; Chikungunya virus - Serology; Chikungunya Virus - Virus; Chikungunya virus - Transmission; Chikungunya virus - Chikungunya fever; Chikungunya virus - Epidemic; Chikungunya virus - Epidemiology; Chikungunya virus - Immunology; Chikungunya virus - Public health
Data de publicação: 2009
