Chikungunya infection in pregnancy: evidence for intrauterine infection in pregnant women and vertical transmission in the parturient. Survey of the Reunion Island outbreak
Autor(es): Lenglet Y, Barau G, Robillard P-Y, R-rianaivo H, Michault A, Bouveret A, Gérardin P, Boumahni B, Touret Y, Kauffmann E, Schuffenecker I, Gabriele M, Fourmaintraux A
Resumo: Since February 2005, an outbreak of Chikungunya virus (CHIKV) infections occurred in Reunion Isl-. It is transmitted by the Aedes albopictus mosquito. Neonatal cases observations suggest possible fetal transmission during pregnancy. MATERIAL [corrected] - METHODS. Observations made in 160 pregnant mothers infected by CHIKV between June 1, 2005 - February 28, 2006, in the south of Reunion isl- were recorded. Three of nine miscarriages before 22 weeks of gestation could be attributed to the virus. 3,829 births took place during this time. Among the 151 infected women, 118 were viremia negative at delivery, - none of the newborns showed any damage. Among the 33 with positive viremia at delivery, 16 newborns (48.5%) presented neonatal Chikungunya. Though fetal contamination risks appear to be rare before 22 weeks of gestation, they are potentially dangerous. After 22 weeks gestation, newborns infection occurs if the mother is viremia positive at delivery. Transplacental transmission is suspected, but the pathogenic mechanism remains unknown.
Palavras-Chave: Chikungunya virus; Arboviruses; Materno-fetal transmission
Imprenta: Journal de Gyne?cologie, v. 35, n. 6, p. 578-583, 2006
Identificador do objeto digital: JGYN-10-2006-35-6-0368-2315-101019-200605061
Descritores: Chikungunya virus - Pathogenesis; Chikungunya virus - Infectious diseases; Chikungunya virus - Inflammation; Chikungunya virus - Viral infections; Chikungunya Virus - Virus; Chikungunya virus - Transmission; Chikungunya virus - Epidemiology; Chikungunya virus - Public health
Data de publicação: 2006
