New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti
Autor(es): Gulzar, Tahsin; Uddin, Nizam; Siddiqui, Bina; Naqvi, Syed; Begum, Sabira; Tariq, Rajput
Resumo: Six bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EI-MS, FAB-MS, 1H and 13C NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (1Ha1H COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method.
Palavras-Chave: Pesticides; Larvae; Pest control; Bioactive compounds; Public health; Seeds; Dengue; Yellow fever; Vectors; Aedes aegypti; Piper nigrum
Imprenta: Phytochemistry Letters, v. 6, n. 2, p. 219-223, 2013.
Descritores: Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Public health
Data de publicação: 2013
