Autor(es): M. S., Rafael; Hereira-Rojas, W. J.; Roper, J. J.; Nunomura, S. M.; Tadei, W. P.

Resumo: Dillapiol, a phenylpropanoid isolate from essential oils of leaves of Piper aduncum (Piperaceae), has insecticidal, fun-gicidal and antimicrobial activities. The insecficidal activity of dillapiol was tested in vivo on the larvae and pupae of Aedes aegypti, the mosquito vector of dengue. Specifically, the effect of dillapiol on the formation of micronuclei and chromosome aberrations was analyzed. Dillapiol treatments comprised two concentrations of 200 and 400 kg/mL, dissolved in well water, and a pure well water control used to rear four generations of mosquitoes. Micronuclei occurred in mitotic diploid and tetraploid chromosomes of larvae; nuclear abnormalities also occurred in interphase, metaphase, telophase, and single nucleus cells of pupae. Mortality, oviposition, chromosome breakage, and anaphase bridges were significantly greater in the extract treatments than in controls. The genotoxic effects of dillapiol described here suggest that this natural product may be a useful alternative for the control of A. aegypti.

Imprenta: Genetics and Molecular Research, V. 7, n. 3, p. 772-781, 2008.

Descritores: Aedes aegypti - Cell ; Aedes aegypti - Dengue ; Aedes aegypti - Public health

Data de publicação: 2008