Larvicidal activity against Aedes aegypti of some plants native to the West-Central region of Brazil
Autor(es): Garcez, Walmir S.; Garcez, Fernanda R.; Da Silva, Lilliam M. G. E.; Hamerski, Lidilhone
Resumo: A total of 42 ethanolic extracts from 30 different plant species, native to the Pantanal and Cerrado of the West-Central region of Brazil, have been evaluated for their larvicidal activity against Aedes aegypti larvae, the vector of dengue and dengue hemorrhagic fevers. Among the extracts tested, that obtained from the trunk bark of Ocotea velloziana was the most active. Using a bioassay-directed fractionation of this extract, the active constituent was isolated and characterized as the aporphine alkaloid (+)-dicentrine. Its structure was established on the basis of super(1)H and super(13)C NMR spectra, optical rotation and by comparison with an authentic sample. This is the first report on the larvicidal activity against A. aegypti of this alkaloid. Our results suggest that (+)-dicentrine may be considered as a promising natural mosquito larvicidal agent.
Palavras-Chave: Molecular structure; Human diseases; Alkaloids; Pesticides; Larvae; Pest control; Public health; Dengue hemorrhagic fever; Vectors; Bark; Plant extracts; Dicentrine
Imprenta: Bioresource Technology, v. 100, n. 24, p. 6647-6650, 2009.
Descritores: Aedes aegypti - Molecular Structure ; Aedes aegypti - Dengue ; Aedes aegypti - Public health
Data de publicação: 2009
