Immunotoxicity activity of sesquiterpenoids from black galingale (Kaempferia parviflora Wall. Ex. Baker) against Aedes aegypti L.
Autor(es): Moon, H. L.; Cho, S. B.; Lee, J. H.; Paik, H. D.; Kim, S. K.
Resumo: The roots of black galingale (Kaempferia parviflora) were chloroform-extracted and the isolated two sesquiterpene and immunotoxicity effects were studied. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including UV, MS, super(1)H-NMR, and super(13)C-NMR as follows: 1 (4a-acetoxycadina-2, 9-diene-l, 8-dione), 2 (l alpha , 3 alpha , 4 beta -trihydroxy-9-cadinen-8-one). Compound 2 had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L. with an LC sub(50) value of 0.7 sigma M and an LC sub(90) value of 3.8 sigma M. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
Palavras-Chave: Aedes aegypti; Kaempferia parviflora; Black galingale; Sesquiterpene; Immunotoxicity effects
Imprenta: Immunopharmacology and Immunotoxicology, v. 33, n. 2, p. 380-383, 2011.
Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Immunology
Data de publicação: 2011
