Autor(es): Moon, H. I.; Zee, O.

Resumo: The whole plants of Carpesium rosulatum were chloroform extracted and the isolated sesquiterpene lactones and immunotoxicity effects were studied. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including mp, [ alpha ] super(2) sub(D) super(5), IR, UV, EI-MS, MS, super(1)H-NMR, super(13)C-NMR and some chemical transformations as follows: 1 (4 beta , 10 alpha -dihydroxy-guaian-8 alpha , 12-olide), 2 (4 beta 10 alpha -dihydroxy-1(2), 11 (13)-guaiadien -8 alpha , 12-olide), 3 (3 beta ,8 beta -dihydroxy-l alpha , 5 alpha -guaian-10(14)-ene-6 alpha , 12-olide). 4 (2 beta , 5-epoxy-5,10-dihydroxy-6 alpha , 9 beta -diangeloyloxy-germacran-8 alpha , 12-olide) The chloroform extracted had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC sub(50) value of 13.11 ppm and an LC sub(90) value of 20.33 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.

Palavras-Chave: Aedes aegypti; Carpesium rosulatum; Sesquiterpene lactone; Immunotoxicity effects

Imprenta: Immunopharmacology and Immunotoxicology, v. 33, n. 2, p. 338-341, 2011.

Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Immune response ; Aedes aegypti - Immunology

Data de publicação: 2011

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