Immunotoxicity activity of 2,6,10,15-tetrame-heptadecane from the essential oils of Clerodendron trichotomum Thunb. against Aedes aegypti L
Autor(es): Lee, S. J.; Moon, H. I.
Resumo: The leaf parts of Clerodendron trichotomum were extracted and the major essential oils composition and immunotoxicity effects were studied. The analyses were conducted by gas chromatography-mass spectroscopy (GC-MS) revealed that the essential oils of C. trichotomum (CTEO). The CTEO yield was 0.071%, and GC/MS analysis revealed that its major constituents were Hexanal (3.31%), 5-Me-3-heptanone (1.71%), 2,6,6-trime-cyclohexanone (2.23%), 2,6,10,15-tetrame-heptadecane (24.21%) and Linalool (31.2%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC sub(50) value of 32.78 ppm and an LC sub(90) value of 93.72 ppm. 2,6,10,15-tetrame-heptadecane was the most toxic among the two major components (2,6,10,15-tetrame-heptadecane and Linalool), with an LC sub(50) value near 43.9 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
Palavras-Chave: Aedes aegypti; Clerodendron trichotomum; Essential oils; Immunotoxicity effects
Imprenta: Immunopharmacology and Immunotoxicology, v. 32, n. 4, p. 705-707, 2010.
Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Immunology
Data de publicação: 2010
