The toll and Imd pathways are not required for Wolbachia-mediated dengue virus interference
Autor(es): Rances, Edwige; Johnson, Travis K.; Popovici, Jean; Iturbe-Ormaetxe, Inaki; Zakir, Tasnim; Warr, Coral G.; O'Neill, Scott L.
Resumo: Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
Palavras-Chave: Virology; Mutations; Replication; Phenotypes; Aquatic insects; Public health; Dengue; Immune system; Mutation; Models; Insects; Dengue virus; Aedes aegypti; Wolbachia; Drosophila melanogaster
Imprenta: Journal of Virology, v. 87, no. 21, p. 11945-11949, 2013.
Descritores: Aedes aegypti - Virus ; Aedes aegypti - Dengue ; Aedes aegypti - Immunology
Data de publicação: 2013
