Neurological complications in dengue infection: a review for clinical practice
Autor(es): Puccioni-Sohler, M.; Rosadas, C.; Cabral-Castro, M. J.
Resumo: Dengue is an important global public health problem. The World Health Organization estimates that 2/5 of entire world population are in risk of dengue infection. Almost 50 millions cases occur annually, with at least 20 thousand deaths. The etiological agent of this acute febrile disease is a single-strand positive-sense RNA virus of Flavivirus genus. It is an arboviral disease transmitted by Aedes sp. mosquitoes (Aedes aegypti and A. albopictus). Most infected individuals present asymptomatic infection, but some may develop clinical signs. Therefore, a wide spectrum of illness can be observed, ranging from unapparent, mild disease, called dengue fever, to a severe and occasionally fatal dengue hemorrhagic fever/dengue shock syndrome. Currently, neurological manifestations related to dengue infections are increasingly been observed and appears as a challenge for medical practice. In this study the neurological complications of dengue infection will be reviewed, focusing a better understanding of the disease for the clinical practice.Original Abstract: A dengue e um importante problema de saude publica. A Organizacao Mundial de Saude estima que 2/5 da populacao mundial encontra-se em risco de desenvolver a infeccao. Cerca de 50 milhoes de casos ocorrem anualmente, com ao menos 20 mil mortes. O agente etiologico desta doenca febril aguda e um virus RNA, do genero Flavivirus. Este arbovirus e transmitido pelo mosquito Aedes sp. A maioria dos individuos infectados apresenta infeccao assintomatica, porem alguns desenvolvem sintomas clinicos. Estes manifestacoes podem variar desde uma doenca inaparente, branda, conhecida como febre da dengue, ate uma forma severa, sendo fatal em alguns casos como na febre hemorragica da dengue/sindrome de choque da dengue. Atualmente, manifestacoes neurologicas associadas a dengue sao cada vez mais frequentes, tornando-se um desafio na rotina medica. Neste estudo, as complicacoes neurologicas da dengue serao revisadas, com enfase na melhor compreensao acerca da doenca para a pratica clinica.
Palavras-Chave: Symptoms; Disease transmission; Public health; Dengue hemorrhagic fever; Shock; Dengue; Neurological complications; RNA viruses; Asymptomatic infection; Mortality; Infection; Aedes aegypti
Imprenta: Arquivos de Neuro-Psiquiatria; v. 71, n. 9B, p. 667-671, 2013.
Descritores: Aedes aegypti - Biochemistry ; Aedes aegypti - RNA ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health
Data de publicação: 2013
