Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
Autor(es): Wen, Jinsheng; Ngono, Annie Elong; Regla-Nava, Jose Angel; Kim, Kenneth; Gorman, Matthew J.; Diamond, Michael S.; Shresta, Sujan
Resumo: Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1?/? or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8+ T cells predominantly mediate cross-protective responses to ZIKV. In contrast, passive transfer studies suggest that DENV-immune serum does not protect against ZIKV infection. Thus, CD8+ T cell immunity generated during primary DENV infection can confer protection against secondary ZIKV infection in mice. Further optimization of current DENV vaccines for T cell responses might confer cross-protection and prevent antibody-mediated enhancement of ZIKV infection.
Palavras-Chave: Antibodies; CD8-positive T cells; Dengue virus; Viral infection
Imprenta: Nature Communications, n. 1459, 2017
Identificador do objeto digital: 10.1038/s41467-017-01669-z
Descritores: Zika virus - Cell ; Zika virus - Protein synthesis ; Zika virus - Infectious diseases
Data de publicação: 2017
