Congenital Zika Virus infection induces severe spinal cord injury
Autor(es): Ramalho, Fernando S.; Yamamoto, Aparecida Y.; Silva, Luis L. da; Figueiredo, Luiz T. M.; Rocha, Lenaldo B.; Neder, Luciano; Teixeira, Sara R.; Apolinário, Letícia A.; Ramalho, Leandra N. Z.; Silva, Deisy M.; Coutinho, Conrado M.; Melli, Patrícia P.; Augusto, Marlei J.; Santoro, Ligia B.; Duarte, Geraldo; Mussi-Pinhata, Marisa M.
Resumo: We report 2 fatal cases of congenital Zika virus (ZIKV) infection. Brain anomalies, including atrophy of the cerebral cortex and brainstem, and cerebellar aplasia were observed. The spinal cord showed architectural distortion, severe neuronal loss, and microcalcifications. The ZIKV proteins and flavivirus-like particles were detected in cytoplasm of spinal neurons, and spinal cord samples were positive for ZIKV RNA.
Palavras-Chave: Zika virus; Flavivirus; Spinal cord injury; Cortical atrophy; Cerebellar aplasia
Imprenta: Clinical Infectious Diseases, v. 65, n. 4, p. 687-690, 2017
Identificador do objeto digital: 10.1093/cid/cix374
Descritores: Zika virus - Flaviviridae ; Zika virus - RNA ; Zika virus - Viral infections ; Zika virus - RNA virus
Data de publicação: 2017
