Linking dengue virus entry and translation/replication through amphisomes
Autor(es): Panyasrivanit, Mingkwan; Khakpoor, Atefeh; Wikan, Nitwara; Smith, Duncan R.
Resumo: Amphisomes are preautolysosomal vacuoles formed upon the fusion of autophagosomes with endosomes, and as such represent a critical meeting point between endocytic and autophagic pathways. Dengue virus enters into susceptible cells by clathrin-mediated endocytosis, and colocalization of dengue markers with markers of both autophagic and endosomal vesicles demonstrates that amphisomes are a site of dengue virus replication and translation. This work links for the first time the processes of dengue virus entry and translation/replication, and allows for interpretation of the early part of the dengue virus life cycle in terms of a continual association with membranes of an endosomal-autophagosomal lineage.
Palavras-Chave: Amphisome; Autophagy; Dengue; Endosome; Replication; Translation
Imprenta: Autophagy, v. 5, n. 3, p. 434-435, 2009
Descritores: Aedes aegypti - Cell ; Aedes aegypti - RNA
Data de publicação: 2009
