Larvicides and acetyi-cholinesterase inhibitors from Kalanchoe species.
Autor(es): Salles Trevisan, Maria Teresa; Barbosa Bezerra, Maria Zeneide; Pinheiro Santiago, Gilvandete Maria; Feitosa, Chistiane Mendes; Verpoorte, Robert; Braz Filho, Raimundo
Resumo: Acetylcholine esterase inhibitors are successfully used to treat the symptoms of Alzheimer's disease. Extracts of three Kalanchoe species (K. brasiliensis, K. pinnata and K. gastonis-bornieri) showed acetylcholine esterase inhibitory effects and a toxic effect on Aedes aegypti larvae. Here we describe the bioassay guided fractionation of extracts of the most active extracts (K. brasiliensis) which resulted in the isolation of an active mixture of three flavonoids: 8-methoxyquercetin, 3,7-di-O-rhaninopyranoside and 8-methoxykaempferol-3.7-di-O-rhamnopyranoside. On TLC these flavonoids showed an acetylcholine esterase inhibitory effect.
Palavras-Chave: Kalanchoe Species; Flavonol Glycosides; Alzheimer's Disease
Imprenta: Quimica Nova, v. 29, n. 3, p. 415-418, 2006
Identificador do objeto digital: 10.1590/S0100-40422006000300002
Descritores: Aedes aegypti - Larvicide
Data de publicação: 2006
