Autor(es): Larson, Ryan T.; Wessely, Vilena; Jiang, Zhisheng; Lan, Que

Resumo: A previous report has shown that mosquito sterol carrier protein-2 inhibitors (SCPIs) are larvicidal to larvae of the yellowfever mosquito, Aedes aegypti (L.) (J. Lipid Res. 46:650-657,2005). In the current study, we tested SCPI-1 in an additional four mosquito species for larvicidal activities: Culex pipiens pipiens, Anopheles gambiae, Culex restuans, and Aedes vexans. Cholesterol accumulation in SCPI-treated Ae. aegypti fourth instars was examined. SCPI-1 is lethal to all tested mosquito species, with the LC50 value ranging from 5.2 to 15 mu M when treatments started at the first to third instar. However, LC50 values increase to from 5.2 to 38.7 mu M in treatments started at first and fourth instar, respectively. The results indicate that the lethal effect of SCPI-1 decreases with the growth of larvae, which suggests that SCPI-1 is more effective before the larvae reach final growth period (the last instar). SCPI-1 suppressed cholesterol uptake in Ae. aegypti fourth instars, suggesting that one of the modes of action of SCPI-1. is via reduction in cholesterol absorption.

Palavras-Chave: Cholesterol; Insecticide; Larvicide; Aedes; Sterol Carrier Protein

Imprenta: Journal of Medical Entomology, v. 45, n. 3, p. 439-444, 2008

Identificador do objeto digital: 10.1603/0022-2585(2008)45[439:LAOSCP]2.0.CO;2

Descritores: Aedes aegypti - Larvicide

Data de publicação: 2008