Larvicidal Activity Of Naturally Occurring Naphthalenedione And Its Structurally Related Analogs Against Three Mosquito Species
Autor(es): Jeon, Ju-Hyun; Kim, Min-Gi; Lee, Hoi-Seon
Resumo: The objective of this study was to determine the larvicidal activity of an active compound isolated from Cercis chinensis heartwood and its structurally related analogs against 4th-stage Aedes aegypti, Culex pipiens pallet's, and Ae. togoi. The larvicidal compound of C. chinensis was isolated with the use of various chromatographic techniques and identified as analogs of 1,4-naphthalenedione. Based on the median lethal concentration (LC50) values of commercially procured analogs against Ae. aegypti larvae, the most toxic analog was 2-bromo-1,4-naphthalenedione (1.19 mu g/ml); followed by 5-hydroxy-1,4-naphthalenedione (1.72 mu g/ml); 2-methyl-1,4-naphthalenedione (9.12 mu g/ml); 2-hydroxy-1,4-naphthalenedione (10.76 mu g/ml); and 2-methoxy-1,4-naphthalenedione (12.50 mu g/ml). Similar results were observed against Cx. p. pallens and Ae. togoi larvae with 1,4-naphthalenedione analogs. These results also showed that 1,4-naphthalenedione analogs were less toxic than the organophosphate pirimiphos-methyl. Nonetheless, naturally occurring C. chinensis derived materials and 1,4-naphthalenedione analogs have potential for development as mosquito larvicidal agents.
Palavras-Chave: Aedes Aegypti; Cercis Chinensis; Culex Pipiens Pallens; Mosquito Larvicidal Activity; Ae. Togoi
Imprenta: Journal of the American Mosquito Control Association, v. 31, n. 1, p. 71-76, 2015
Descritores: Aedes aegypti - Larvicide ; Aedes aegypti - Public health
Data de publicação: 2015
