Infection barriers and responses in mosquito-filarial worm interactions
Autor(es): Bartholomay, Lyric C.
Resumo: As a function of size, migration trajectory through the body and developmental site, filarial worm parasites inflict significant damage on the mosquito host. Some mosquitoes are equipped with physical and physiological barriers that confer a refractory state to parasite infection. In a susceptible host, parasites migrate to a developmental site and achieve an intracellular existence; during this process, worms elicit canonical mosquito immune response elements, particularly melanization and antimicrobial peptide (AMP) production. It is clear now that the response to infection also involves mitigating stress and manipulation of host cell machinery to delay necrosis. This review focuses on mechanisms of refractoriness and resistance to Brugia malayi, Brugia pahangi, and Dirofilaria immitis, with emphasis on infection in the mosquito, Aedes aegypti.
Imprenta: Current Opinion in Insect Science, v. 3, p. 37-42, 2014
Identificador do objeto digital: 10.1016/j.cois.2014.08.006
Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Molecular structure ; Aedes aegypti - Immune response ; Aedes aegypti - Immunology ; Aedes aegypti - Public health
Data de publicação: 2014
