Autor(es): Bharathi, A.; Roopan, Selvaraj Mohana; Rahuman, Abdul Abdul; Rajakumar, Govindasamy

Resumo: Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties. The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives 4a-f. A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[j][1,7] phenanthroline-3- carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-IR, H-1 NMR, C-13 NMR, and ESI Mass analysis data. All the synthesized compounds were evaluated for larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. Furthermore, the antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. From the antioxidant assay, the compound 4c was reported with profound antioxidant potential.

Palavras-Chave: Radical Scavenging Activity; N-Alkylpyridinium Salts; Carbon Nucleophiles; Alkaloid Synthesis; Dihydropyridines; Derivatives; Acridine

Imprenta: Biomed Research International, 2014

Identificador do objeto digital: 10.1155/2014/915797

Descritores: Aedes aegypti - Larvicide

Data de publicação: 2014