Autor(es): Leite, Ana Carolina C. F.; Kato, Massuo J.; Soares, Renata O. A.; Guimaraes, Anthony E.; Santos-Mallet, Jacenir R.; Cabral, Marise M. O.

Resumo: Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective Vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 mu g/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 mu g/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.

Palavras-Chave: Aedes Aegypti; Piper Solmsianum; Histology; Toxicity; Tropical Disease

Imprenta: Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, v. 22, n. 3, p. 517-521, 2012

Identificador do objeto digital: 10.1590/S0102-695X2012005000016

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - Larvicide ; Aedes aegypti - Vaccine ; Aedes aegypti - Public health

Data de publicação: 2012