Autor(es): Friedman, Robert

Resumo: Cytosolic glutathione S-transferases (GSTs) are a large and diverse gene family in insects. They are classified into six major subclasses. Sigma, Omega, Zeta, and Theta have representatives across Metazoa while Delta and Epsilon are specific to Insects and Holometabola, respectively. In this study, GSTs are assigned to a subclass by a combination of literature, phylogenetic, and genomic evidence. Moreover, it is confirmed that GSTs frequently cluster by genomic position as a result of recent gene expansions. These expansions are largely explained by the number of protein-coding genes in the genome, although life history is another contributing factor. (C) 2011 Elsevier Inc. All rights reserved.

Palavras-Chave: Glutathione transferases; Gene duplication; Genomic organization

Imprenta: Molecular Phylogenetics and Evolution, v. 61, n. 3, p. 924-932, 2011

Identificador do objeto digital: 10.1016/j.ympev.2011.08.027

Descritores: Aedes aegypti - Genome

Data de publicação: 2011